Glucose was the main energy source for the brain. The decrease in blood glucose was incompatible with the continuity of life. For this, maintaining the blood sugar level was secured by many alternative systems. Increased appetite was one of the main protection mechanisms against hypoglycemia.
Changing nutrition and living habits with the industrial revolution made metabolic diseases an important global public health problem. Now, compared to a hundred years ago, we provide food more easily, consume more and act less to obtain food.
Behavioral effects of high fat diet on glutamatergic neurons in the hypothalamus.